Article

Single-cell RNA-seq profiles of intestinal mucosa in IBS-D rats to explore the mechanism of immune barrier regulation in pathogenesis

2026-04-26

Abstract excerpt

<title>Abstract</title> <p>Imbalance of intestinal mucosal immune regulation is a key mechanism in diarrhea-predominant irritable bowel syndrome (IBS-D). We aimed to characterize this dysregulation in the intestinal mucosa at single-cell resolution. Intestinal mucosal cells from control and neonatal maternal separation-induced IBS-D rats were isolated and subjected to single-cell RNA sequencing (scRNA-seq). Bioin...

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Literature Corpus work: c8db88c8-dfd0-5879-b7df-d146d5bb16e1
DOI: 10.21203/rs.3.rs-9205401/v1

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