Article
Regulation of bestrophins by Ca2+: a theoretical and experimental study.
PloS one - 1 Jan 2009
Kranjc Agata, Grillo Federico W, Rievaj Juraj, Boccaccio Anna, Pietrucci Fabio, Menini Anna, Carloni Paolo, Anselmi Claudio
Abstract excerpt
Bestrophins are a recently discovered family of Cl(-) channels, for which no structural information is available. Some family members are activated by increased intracellular Ca2+ concentration. Bestrophins feature a well conserved Asp-rich tract in their COOH terminus (Asp-rich domain), which is homologous to Ca2+-binding motifs in human thrombospondins and in human big-conductance Ca2+- and voltage-gated K+...
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