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Genetic mutations and molecular mechanisms of Fuchs endothelial corneal dystrophy

15 Jun 2021

Abstract excerpt

BACKGROUND: Fuchs endothelial corneal dystrophy is a hereditary disease and the most frequent cause of corneal transplantation in the worldwide. Its main clinical signs are an accelerated decrease in the number of endothelial cells, thickening of Descemet's membrane and formation of guttae in the extracellular matrix. The cornea's ability to maintain stromal dehydration is impaired, causing painful epithelial...

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PMID: 34130750
DOI: 10.1186/s40662-021-00246-2

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