Article

Immunopeptidomics-guided identification of functional neoantigens in non-small cell lung cancer

2024-06-02

Abstract excerpt

Non-small cell lung cancer (NSCLC) has poor survival even with modern checkpoint inhibitor therapies. Personalised vaccines based on short peptide neoantigens containing tumour mutations are an attractive precision medicine strategy, but identifying therapeutically relevant neoantigens remains challenging, with existing methods yielding positive responses in only 6% of candidates tested. We developed an immunopept...

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Literature Corpus work: 0e70163b-5b25-5fc1-8f0b-cc41a109e83e
DOI: 10.1101/2024.05.30.596609

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