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Article

PSSMHCpan: a novel PSSM-based software for predicting class I peptide-HLA binding affinity.

GigaScience - 1 May 2017

Liu Geng, Li Dongli, Li Zhang, Qiu Si, Li Wenhui, Chao Cheng-Chi, Yang Naibo, Li Handong, Cheng Zhen, Song Xin, Cheng Le, Zhang Xiuqing, Wang Jian, Yang Huanming, Ma Kun, Hou Yong, Li Bo

Abstract excerpt

Predicting peptide binding affinity with human leukocyte antigen (HLA) is a crucial step in developing powerful antitumor vaccine for cancer immunotherapy. Currently available methods work quite well in predicting peptide binding affinity with HLA alleles such as HLA-A*0201, HLA-A*0101, and HLA-B*0702 in terms of sensitivity and specificity. However, quite a few types of HLA alleles that are present in the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28327987
DOI: 10.1093/gigascience/gix017
PMCID: PMC5467046

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