Article

EZH2 Abundance Regulated by UHRF1/UBE2L6/UBR4 Ubiquitin System is the Potential Therapeutic Target to Trigger Pigmented Phenotype in Melanoma

2021-03-06

Abstract excerpt

<h4>ABSTRACT</h4> Cellular heterogeneity in cancer is linked to disease progression and therapy response, although the mechanisms regulating distinct cellular states within tumours are not well understood. To address this, we identified melanin pigment content as a major source of phenotypic and functional heterogeneity in melanoma and compared RNAseq data from high (HPC) and low pigmented melanoma cells (LPC), r...

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Literature Corpus work: 7061a45d-4b3a-539b-884a-cd50482ff8f8
DOI: 10.1101/2021.03.04.433988

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