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Article

UHRF1/UBE2L6/UBR4-mediated ubiquitination regulates EZH2 abundance and thereby melanocytic differentiation phenotypes in melanoma.

Oncogene - 1 Apr 2023

Kuser-Abali Gamze, Zhang Youfang, Szeto Pacman, Zhao Peinan, Masoumi-Moghaddam Samar, Fedele Clare G, Leece Isobel, Huang Cheng, Cheung Jen G, Ameratunga Malaka, Noguchi Fumihito, Andrews Miles C, Wong Nicholas C, Schittenhelm Ralf B, Shackleton Mark

Abstract excerpt

Cellular heterogeneity in cancer is linked to disease progression and therapy response, although mechanisms regulating distinct cellular states within tumors are not well understood. We identified melanin pigment content as a major source of cellular heterogeneity in melanoma and compared RNAseq data from high-pigmented (HPCs) and low-pigmented melanoma cells (LPCs), suggesting EZH2 as a master regulator of these...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36906655
DOI: 10.1038/s41388-023-02631-8
PMCID: PMC10121471

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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