Article

Identification of targetable epigenetic vulnerabilities for uveal melanoma

2024-10-11

Abstract excerpt

<h4>ABSTRACT</h4> Uveal melanoma (UM) is the most common primary intraocular malignancy in adults, with a strong predilection for hepatic metastasis, occurring in approximately 50% of cases. Metastatic UM remains highly resistant to therapy and is almost invariably fatal. The strongest genetic drivers of UM metastasis are loss-of-function mutations in tumor suppressor BAP1 , an epigenetic regulator that serves a...

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Literature Corpus work: e9222ec5-4a08-5d68-8e46-9ff6df8bf2b2
DOI: 10.1101/2024.10.11.617464

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