Article

Multiple-testing corrections in case-control studies using identity-by-descent segments

2025-07-07

Abstract excerpt

Identity-by-descent (IBD) mapping provides complementary signals to genome-wide association studies (GWAS) when multiple causal haplotypes or variants are present, but not directly tested. However, failing to correct for multiple testing in case-control studies using IBD segments can lead to false discoveries. We propose the difference between case-case and control-control IBD rates as an IBD mapping statistic. Fo...

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Literature Corpus work: 704ddb3b-d78c-59ea-96c7-e7a8d7627997
DOI: 10.1101/2025.07.03.663057

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