Article
Multiple-testing corrections in case-control studies using identity-by-descent segments.
American journal of human genetics - 5 Mar 2026
Temple Seth D, Chapman Nicola H, Choi Seung Hoan, DeStefano Anita L, Thornton Timothy A, Wijsman Ellen M, Blue Elizabeth E
Abstract excerpt
Identity-by-descent (IBD) mapping provides complementary signals to genome-wide association studies (GWASs) when multiple causal haplotypes or variants are present but not directly tested. We propose the difference between affected-affected and control-control IBD rates as an IBD mapping statistic. For our hypothesis test, we use a computationally efficient approach from the stochastic processes literature to...
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