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Article

Spatial Measures of Genetic Heterogeneity During Carcinogenesis.

Bulletin of mathematical biology - 1 Feb 2017

Storey K, Ryser M D, Leder K, Foo J

Abstract excerpt

In this work we explore the temporal dynamics of spatial heterogeneity during the process of tumorigenesis from healthy tissue. We utilize a spatial stochastic model of mutation accumulation and clonal expansion in a structured tissue to describe this process. Under a two-step tumorigenesis model, we first derive estimates of a non-spatial measure of diversity: Simpson's Index, which is the probability that two...

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Identifiers

PMID: 27905065
DOI: 10.1007/s11538-016-0234-5
PMCID: PMC6065111

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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