Article

The gut metabolite indole-3-propionic acid activates ERK1 to restore social function and hippocampal inhibitory synaptic transmission in a 16p11.2 microdeletion mouse model

2023-04-06

Abstract excerpt

<h4>Background: </h4> Microdeletion of the 16p11.2 region of the human chromosome is a prevalent genetic factor for autism spectrum disorder (ASD) and other neurodevelopmental disorders, but its pathogenic mechanism remains unclear, and effective treatments for 16p11.2 microdeletion syndrome are lacking. Emerging evidence suggests that the gut microbiota and its metabolites are inextricably linked to host behavior...

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Literature Corpus work: 8b8414d4-18d3-559d-9cc6-5978857f35eb
DOI: 10.21203/rs.3.rs-2774761/v1

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