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Article

Involvement of human monogenic cardiomyopathy genes in experimental polygenic cardiac hypertrophy.

Physiological genomics - 1 Sept 2018

Prestes P R, Marques F Z, Lopez-Campos G, Lewandowski P, Delbridge L M D, Charchar F J, Harrap S B

Abstract excerpt

Hypertrophic cardiomyopathy thickens heart muscles, reducing functionality and increasing risk of cardiac disease and morbidity. Genetic factors are involved, but their contribution is poorly understood. We used the hypertrophic heart rat (HHR), a unique normotensive polygenic model of cardiac hypertrophy and heart failure, to investigate the role of genes associated with monogenic human cardiomyopathy. We...

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PMID: 29775428
DOI: 10.1152/physiolgenomics.00143.2017

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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