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Macrophage-induced rifampin tolerance across Mycobacterium tuberculosis lineages is Rv1258c-dependent

2018-08-03

Abstract excerpt

<h4>ABSTRACT</h4> The Mycobacterium tuberculosis (Mtb) Lineage 4 strains CDC1551 and H37Rv develop tolerance to multiple antibiotics upon macrophage residence. Genetic mutation of the efflux pump Rv1258c in CDC1551 abolishes rifampin tolerance but not isoniazid tolerance. Here we show that clinical isolates from the other predominant Mtb lineages developed macrophage-induced isoniazid tolerance. Furthermore, all...

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Identifiers and source

Literature Corpus work
6ff74725-3f2a-521d-bfdf-42bbd1c42d37
DOI
10.1101/383109
Open publication

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Macrophage-induced rifampin tolerance across Mycobacterium tuberculosis lineages is Rv1258c-dependentDOI 10.1101/383109
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