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Article

Novel mutation in efflux pump Rv1258c (Tap) gene in drug resistant clinical isolates of Mycobacterium tuberculosis in Iran.

Journal of infection in developing countries - 29 Feb 2024

Farzaneh ShimaSadat, Norouzi Fatemeh, Fazeli Hossein, Salehi Mahshid, Safari Marzieh, Nasr Esfahani Bahram

Abstract excerpt

INTRODUCTION: Tuberculosis (TB) remains a serious public health problem worldwide. Drug-resistant TB is considered a major and growing global threat. Despite the great variety of described mutations in Mycobacterium tuberculosis (MTB) resistance genes, the mechanisms of drug resistance are still controversial. Recently, a report on the role of efflux pump genes in drug resistance added to this complexity....

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PMID: 38484347
DOI: 10.3855/jidc.18634

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