Article
Rifampicin-induced transcriptome response in rifampicin-resistant Mycobacterium tuberculosis.
Tuberculosis (Edinburgh, Scotland) - 1 Jan 2013
de Knegt Gerjo J, Bruning Oskar, ten Kate Marian T, de Jong Mark, van Belkum Alex, Endtz Hubert P, Breit Timo M, Bakker-Woudenberg Irma A J M, de Steenwinkel Jurriaan E M
Abstract excerpt
Tuberculosis (TB) is still a major life-threatening infectious disease, within which especially the rise of multidrug resistant TB (MDR-TB) is currently worrying. This study focuses on mechanisms of development of rifampicin resistance, since rifampicin seems to play an important role in the development of MDR-TB. To provide further insight in rifampicin resistance, we performed a genome-wide transcriptional...
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