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Therapeutic Potential of Tricyclo-DNA antisense oligonucleotides

26 Mar 2016

Abstract excerpt

Oligonucleotide therapeutics hold great promise for the treatment of various diseases and the antisense field is constantly gaining interest due to the development of more potent and nuclease resistant chemistries. Despite a rather low success rate with only three antisense drugs being clinically approved, the frontiers of AON therapeutic applications have increased over the past three decades and continue to...

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PMID: 27854216
DOI: 10.3233/jnd-160146

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