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Antisense Oligonucleotide-Based Therapy of Viral Infections

26 Nov 2021

Abstract excerpt

Nucleic acid-based therapeutics have demonstrated their efficacy in the treatment of various diseases and vaccine development. Antisense oligonucleotide (ASO) technology exploits a single-strand short oligonucleotide to either cause target RNA degradation or sterically block the binding of cellular factors or machineries to the target RNA. Chemical modification or bioconjugation of ASOs can enhance both its...

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PMID: 34959297
DOI: 10.3390/pharmaceutics13122015

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