Article

Proline catabolism is key to facilitating <i>Candida albicans</i> pathogenicity

2023-01-18

Abstract excerpt

Candida albicans , the primary etiology of human mycoses, is well-adapted to catabolize proline to obtain energy to initiate morphological switching (yeast to hyphal) and for growth. We report that put1-/- and put2-/ - strains, carrying defective P roline UT ilization genes, display remarkable proline sensitivity with put2 -/- mutants being hypersensitive due to the accumulation of the toxic intermediate P5C,...

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Literature Corpus work: 6fbb3b18-4191-5d94-9aac-29fb98780b61
DOI: 10.1101/2023.01.17.524449

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