Article

Carbon Dioxide Controls Fungal Fitness and Skin Tropism of <i>Candida auris</i>

2024-04-15

Abstract excerpt

The pronounced skin tropism and pan-antifungal resistance traits of the fungal pathogen Candida auris stand out as a serious health threat. Here, we show that a carbonic sensing pathway (CSP) promotes development of resistance to amphotericin B through a reactive oxygen species (ROS) response, as well as ectopic cell wall and membrane lipid homeostasis. Mechanistically, the transcription factor Rca1 acts in coope...

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Literature Corpus work: fbc8ed50-d1fc-551f-a247-86b9a8295123
DOI: 10.1101/2024.04.12.589292

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