Article

Mitochondrial proline catabolism activates Ras1/cAMP/PKA-induced filamentation in <i>Candida albicans</i>

2018-07-23

Abstract excerpt

Amino acids are among the earliest identified inducers of yeast-to-hyphal transitions in Candida albicans , an opportunistic fungal pathogen of humans. Here, we show that the morphogenic amino acids arginine, ornithine and proline are internalized and metabolized in mitochondria via a PUT1 - and PUT2 -dependent pathway that results in enhanced ATP production. Elevated ATP levels correlate with Ras1/cAMP/PKA pat...

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Literature Corpus work: 52977784-7235-5c4b-9a30-3f883ea3440f
DOI: 10.1101/374777

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