Multimodality Molecular Profiling Nominates Targetable Mechanisms in Progressive RV Dysfunction

Abstract excerpt

<h4>Background</h4> Right ventricular dysfunction (RVD) is a robust predictor of mortality in multiple cardiovascular diseases. Currently, it remains unclear whether the severity of RVD corresponds to distinct cellular and molecular alterations, and this has important implications for defining optimal therapeutic targets. To address this knowledge gap, we performed a multi-omics evaluation of pulmonary artery ban...

Topics

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• Adaptation, Physiological
• Cancer-related molecular mechanisms research
• Cardiac Valve Diseases and Treatments
• Disease Models, Animal
• Gene Expression Profiling
• Hypertension, Pulmonary
• Pulmonary Hypertension Research and Treatments
• RNA modifications and cancer

Identifiers and source

Literature Corpus work

6f92864a-9fa2-55e8-ae88-dc0a4fdc9025

DOI

10.64898/2026.03.09.710504