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Article

Evidence for right ventricular lipotoxicity in heritable pulmonary arterial hypertension.

American journal of respiratory and critical care medicine - 1 Feb 2014

Hemnes Anna R, Brittain Evan L, Trammell Aaron W, Fessel Joshua P, Austin Eric D, Penner Niki, Maynard Karen B, Gleaves Linda, Talati Megha, Absi Tarek, Disalvo Thomas, West James

Abstract excerpt

RATIONALE: Shorter survival in heritable pulmonary arterial hypertension (HPAH), often due to BMPR2 mutation, has been described in association with impaired right ventricle (RV) compensation. HPAH animal models are insulin resistant, and cells with BMPR2 mutation have impaired fatty acid oxidation, but whether these findings affect the RV in HPAH is unknown. OBJECTIVES: To test the hypothesis that BMPR2 mutation...

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Share to Bone Morphogenetic Protein Receptors, Type II
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Familial Primary Pulmonary Hypertension

Share to Hypertension, Pulmonary

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Share to Oligonucleotide Array Sequence Analysis

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Source

Open in PubMed Open full text

Identifiers

PMID: 24274756
DOI: 10.1164/rccm.201306-1086OC
PMCID: PMC3977729

Genes

BMPR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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