Transcriptional profiling unveils molecular subgroups of adaptive and maladaptive right ventricular remodeling in pulmonary hypertension.

doi:10.1038/s44161-023-00338-3

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Transcriptional profiling unveils molecular subgroups of adaptive and maladaptive right ventricular remodeling in pulmonary hypertension.

Nature cardiovascular research - 1 Oct 2023

Khassafi Fatemeh, Chelladurai Prakash, Valasarajan Chanil, Nayakanti Sreenath Reddy, Martineau Sandra, Sommer Natascha, Yokokawa Tetsuro, Boucherat Olivier, Kamal Aryan, Kiely David G, Swift Andrew J, Alabed Samer, Omura Junichi, Breuils-Bonnet Sandra, Kuenne Carsten, Potus Francois, Günther Stefan, Savai Rajkumar, Seeger Werner, Looso Mario, Lawrie Allan, Zaugg Judith B, Tello Khodr, Provencher Steeve, Bonnet Sébastien, Pullamsetti Soni Savai

Abstract excerpt

Right ventricular (RV) function is critical to prognosis in all forms of pulmonary hypertension. Here we perform molecular phenotyping of RV remodeling by transcriptome analysis of RV tissue obtained from 40 individuals, and two animal models of RV dysfunction of both sexes. Our unsupervised clustering analysis identified 'early' and 'late' subgroups within compensated and decompensated states, characterized by...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adaptation, Physiological

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Disease Models, Animal

Share to Gene Expression Profiling

Share to Hypertension, Pulmonary

Share to Sex Factors

Share to Transcriptome

Share to Ventricular Function, Right

Share to Ventricular Remodeling

Source

Open in PubMed Open full text

Identifiers

PMID: 39196250
DOI: 10.1038/s44161-023-00338-3
PMCID: PMC11358157

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Transcriptional profiling unveils molecular subgroups of adaptive and maladaptive right ventricular remodeling in pulmonary hypertension.PMID 39196250Read ↗

Transcriptomic Signature of Right Ventricular Failure in Experimental Pulmonary Arterial Hypertension: Deep Sequencing Demonstrates Mitochondrial, Fibrotic, Inflammatory and Angiogenic AbnormalitiesSemantic proximity Read ↗

Transcriptional Signatures of the Right Ventricle in End-Stage Heart FailureSemantic proximity Read ↗

Molecular Signature of a Right Heart Failure Program in Chronic Severe Pulmonary HypertensionSemantic proximity Read ↗

EGR1 Is Implicated in Right Ventricular Cardiac Remodeling Associated with Pulmonary HypertensionSemantic proximity Read ↗

A common gene signature of the right ventricle in failing rat and human heartsSemantic proximity Read ↗

Transcriptomic profiles reveal differences between the right and left ventricle in normoxia and hypoxiaSemantic proximity Read ↗

Multicellular Programs Associated with Right Ventricular Adaptation in Pulmonary Arterial HypertensionSemantic proximity Read ↗

A common gene signature of the right ventricle in failing rat and human heartsSemantic proximity Read ↗

Multimodal Characterization of High-risk PH-HFpEF phenogroup with Right Ventricular Dysfunction: Vascular Mechanics and Myocardial TranscriptomicsSemantic proximity Read ↗

Deep phenotyping the right ventricle to establish translational MRI biomarkers for characterization of adaptive and maladaptive states in pulmonary hypertension.Semantic proximity Read ↗

Targeted Proteomics of Right Heart Adaptation to Pulmonary Arterial HypertensionSemantic proximity Read ↗

A Multi-omic and Multi-Species Analysis of Right Ventricular FailureSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.