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Article

Geometric cues for directing the differentiation of mesenchymal stem cells

1 Mar 2010

Abstract excerpt

Significant efforts have been directed to understanding the factors that influence the lineage commitment of stem cells. This paper demonstrates that cell shape, independent of soluble factors, has a strong influence on the differentiation of human mesenchymal stem cells (MSCs) from bone marrow. When exposed to competing soluble differentiation signals, cells cultured in rectangles with increasing aspect ratio...

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PMID: 20194780
DOI: 10.1073/pnas.0903269107

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