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Article

Impact of substrate elasticity on human hematopoietic stem and progenitor cell adhesion and motility

1 Jan 2012

Abstract excerpt

In the bone marrow, hematopoietic stem cells (HSCs) reside in endosteal and vascular niches. The interactions with the niches are essential for the maintenance of HSC number and properties. Although the molecular nature of these interactions is well understood, little is known about the role of physical parameters such as matrix elasticity. Osteoblasts, the major cellular component of the endosteal HSC niche,...

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PMID: 22553208
DOI: 10.1242/jcs.095596

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