Article
Piezo1-mediated mechano-energetics regulate CAR T cell function
2025-10-23
Abstract excerpt
<title>Abstract</title> <p>CAR T cell cytotoxicity requires generating immense mechanical force, but the energetic costs of this process remain poorly defined. While metabolic reprogramming fuels effector function, its mechanistic connection to mechanotransduction remains unclear. By directly measuring the synaptic force and mechanical energy of single CAR T cells and linking them to their metabolic state, we pro...
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Identifiers and source
- Literature Corpus work
- be106756-1c58-5936-a6de-dead98e70d5b
- DOI
- 10.21203/rs.3.rs-7776704/v1