Article

IPMK regulates HDAC3 activity and histone H4 acetylation in human cells

2024-04-29

Abstract excerpt

Histone deacetylases (HDACs) repress transcription by catalyzing the removal of acetyl groups from histones. Class 1 HDACs are activated by inositol phosphate signaling molecules in vitro , but it is unclear if this regulation occurs in human cells. Inositol Polyphosphate Multikinase (IPMK) is required for production of inositol hexakisphosphate (IP6), pentakisphosphate (IP5) and certain tetrakisphosphate (IP4) s...

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Literature Corpus work: 257ff77a-879d-5a34-b4ae-b3bd219d8f1c
DOI: 10.1101/2024.04.29.591660

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