Article
The role of mutation of metabolism-related genes in genomic hypermethylation.
Biochemical and biophysical research communications - 5 Dec 2014
Waterfall Joshua J, Killian J Keith, Meltzer Paul S
Abstract excerpt
Genetic mutations, metabolic dysfunction, and epigenetic misregulation are commonly considered to play distinct roles in tumor development and maintenance. However, intimate relationships between these mechanisms are now emerging. In particular, mutations in genes for the core metabolic enzymes IDH, SDH, and FH are significant drivers of diverse tumor types. In each case, the resultant accumulation of particular...
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