Article

The generation of a human cell line to elucidate the role of Fumarate Hydratase loss in cancer

2021-01-01

Abstract excerpt

The reprogramming of cellular metabolism is an established hallmark of cancer, which enables cancer cells to survive, proliferate, and metastasize even under harsh environmental conditions. These cancer-associated metabolic changes can affect several pathways one of which is mitochondrial metabolism. The suppression of mitochondrial metabolism has been associated with poor clinical outcomes and mitochondrial dysfu...

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Literature Corpus work: 3a3f9c77-635a-57be-91cd-652f9e3bd96b
DOI: 10.17863/cam.69474

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