Article

G6b-B regulates an essential step in megakaryocyte maturation

2021-11-12

Abstract excerpt

G6b-B is a megakaryocyte lineage-specific immunoreceptor tyrosine-based inhibition motif (ITIM)-containing receptor, essential for platelet homeostasis. Mice with a genomic deletion of the entire Mpig6b locus develop severe macrothrombocytopenia and myelofibrosis, which is reflected in humans with null-mutations in MPIG6B . The current model proposes that megakaryocytes lacking G6b-B develop normally, while prop...

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Literature Corpus work: 0c94e3c0-6ea7-53fd-83c3-8abad03a3720
DOI: 10.1101/2021.11.11.468226

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