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Article

Dimerization of glycoprotein Ibα is not sufficient to induce platelet clearance.

Journal of thrombosis and haemostasis : JTH - 1 Feb 2016

Liang X, Syed A K, Russell S R, Ware J, Li R

Abstract excerpt

UNLABELLED: ESSENTIALS: Many anti-glycoprotein (GP)Ibα antibodies induce platelet clearance in a dimer-dependent manner. Characterization of monoclonal antibodies that bind the mechanosensitive domain (MSD) of GPIbα. An anti-MSD antibody binds two copies of GPIbα in platelets but does not induce platelet clearance. The prevailing clustering model of GPIbα signaling is incorrect or needs revision. BACKGROUND: The...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26662889
DOI: 10.1111/jth.13221
PMCID: PMC4755834

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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