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Urea transporter B-mediated urea uptake-induced protein carbamylation in platelets underlies bleeding in chronic kidney disease.

Science translational medicine - 19 Aug 2026

Qiu Zhiwei, Xiong Fei, Wang Zhe, Zhao Yingxin, Gao Shuang, Zhang Xin, Chen Yu, Liu Zhiyan, Li Ruofei, Cao Linyu, Sun Lan, Shao Guangying, Sun Tianze, Jiang Tao, Li Min, Dong Jie, Yang Baoxue, Cui Yimin, Xiang Qian

Abstract excerpt

Platelet dysfunction drives bleeding complications in patients with advanced chronic kidney disease (CKD), worsening clinical outcomes. However, the underlying mechanisms remain unclear, limiting treatment options. In this study, we identified the expression of urea transporter B (SLC14A1/UT-B) in human and mouse platelets. By analyzing a clinical cohort of patients with CKD, we demonstrated that...

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Blood Platelets
Hemorrhage
Membrane Transport Proteins
Mice
Mice, Inbred C57BL

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Platelet Glycoprotein GPIIb-IIIa Complex

Renal Insufficiency, Chronic

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Identifiers

PMID: 42616841
DOI: 10.1126/scitranslmed.aed4678

Genes

SLC14A1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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