Article
β4GALT1 controls β1 integrin function to govern thrombopoiesis and hematopoietic stem cell homeostasis.
Nature communications - 17 Jan 2020
Giannini Silvia, Lee-Sundlov Melissa M, Rivadeneyra Leonardo, Di Buduo Christian A, Burns Robert, Lau Joseph T, Falet Hervé, Balduini Alessandra, Hoffmeister Karin M
Abstract excerpt
Glycosylation is critical to megakaryocyte (MK) and thrombopoiesis in the context of gene mutations that affect sialylation and galactosylation. Here, we identify the conserved B4galt1 gene as a critical regulator of thrombopoiesis in MKs. β4GalT1 deficiency increases the number of fully differentiated MKs. However, the resulting lack of glycosylation enhances β1 integrin signaling leading to dysplastic MKs with...
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