Article

Assessment of Growth Parameters and Life Span of GHR/BP Gene-Disrupted Mice

2000-07-01

Abstract excerpt

GH has many biological roles, including promotion of growth. Most, if not all, of its roles are achieved through interaction with its receptor. We chose to study the effects of loss of GH signaling on growth and aging in a mouse model for Laron Syndrome (LS) in which the GHR/BP gene has been disrupted. We observed that mice homozygous for the disruption (−/−) were significantly smaller than normal wild-type (+/+)...

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Literature Corpus work: 6f429246-4cd8-5b02-bf7f-fe47f97d28db
DOI: 10.1210/en.141.7.2608

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