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Article

Is altered expression of hepatic insulin-related genes in growth hormone receptor knockout mice due to GH resistance or a difference in biological life spans?

The journals of gerontology. Series A, Biological sciences and medical sciences - 1 Nov 2009

Panici Jacob A, Wang Feiya, Bonkowski Michael S, Spong Adam, Bartke Andrzej, Pawlikowska Ludmila, Kwok Pui-Yan, Masternak Michal M

Abstract excerpt

Growth hormone receptor knockout (GHRKO) mice live about 40%-55% longer than their normal (N) littermates. Previous studies of 21-month-old GHRKO and N mice showed major alterations of the hepatic expression of genes involved in insulin signaling. Differences detected at this age may have been caused by the knockout of the growth hormone receptor (GHR) or by differences in biological age between GHRKO and N mice....

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Identifiers

PMID: 19706698
DOI: 10.1093/gerona/glp111
PMCID: PMC2759569

Genes

GHR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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