Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Clinical isolates of Mycobacterium tuberculosis in four European hospitals are uniformly susceptible to benzothiazinones.

Antimicrobial agents and chemotherapy - 1 Apr 2010

Pasca Maria Rosalia, Degiacomi Giulia, Ribeiro Ana Luisa de Jesus Lopes, Zara Francesca, De Mori Patrizia, Heym Beate, Mirrione Maurizio, Brerra Roberto, Pagani Laura, Pucillo Leopoldo, Troupioti Panajota, Makarov Vadim, Cole Stewart T, Riccardi Giovanna

Abstract excerpt

The new antitubercular drug candidate 2-[2-S-methyl-1,4-dioxa-8-azaspiro[4.5]dec-8-yl]-8-nitro-6-(trifluoromethyl)-4H-1,3-benzothiazin-4-one (BTZ043) targets the DprE1 (Rv3790) subunit of the enzyme decaprenylphosphoryl-beta-d-ribose 2'-epimerase. To monitor the potential development of benzothia...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antitubercular Agents
Share to Drug Resistance, Multiple, Bacterial

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Europe

Share to In Vitro Techniques

Share to Mycobacterium tuberculosis

Share to Racemases and Epimerases

Share to Spiro Compounds

Share to Tuberculosis, Multidrug-Resistant

Source

Open in PubMed Open full text

Identifiers

PMID: 20086151
DOI: 10.1128/AAC.01676-09
PMCID: PMC2849388

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20086151-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Clinical isolates of Mycobacterium tuberculosis in four European hospitals are uniformly susceptible to benzothiazinones.PMID 20086151Read ↗

Characterization of DprE1-Mediated Benzothiazinone Resistance in Mycobacterium tuberculosis.Semantic proximity Read ↗

Mutations in rv0678 Confer Low-Level Resistance to Benzothiazinone DprE1 Inhibitors in Mycobacterium tuberculosis.Semantic proximity Read ↗

Side Chain-modified Benzothiazinone Derivatives with Anti-Mycobacterial ActivitySemantic proximity Read ↗

Mutations in <i>rv0678</i> confer low-level resistance to benzothiazinone DprE1 inhibitors in <i>M. tuberculosis</i>Semantic proximity Read ↗

Comparative transcriptomic profiling of pyrazinamide resistance in Mycobacterium tuberculosis.Semantic proximity Read ↗

1,4-Azaindole, a Potential Drug Candidate for Treatment of TuberculosisSemantic proximity Read ↗

Discovery of pyrazolopyridones as a novel class of noncovalent DprE1 inhibitor with potent anti-mycobacterial activity.Semantic proximity Read ↗

Resistance to Thiacetazone Derivatives Active against Mycobacterium abscessus Involves Mutations in the MmpL5 Transcriptional Repressor MAB_4384.Semantic proximity Read ↗

Determinants of the Inhibition of DprE1 and CYP2C9 by Antitubercular ThiophenesSemantic proximity Read ↗

N-methylation of a bactericidal compound as a resistance mechanism in Mycobacterium tuberculosis.Semantic proximity Read ↗

2-Carboxyquinoxalines kill mycobacterium tuberculosis through noncovalent inhibition of DprE1.Semantic proximity Read ↗

Tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide and N-benzyl-6',7'-dihydrospiro[piperidine-4,4'-thieno[3,2-c]pyran] analogues with bactericidal efficacy against Mycobacterium tuberculosis targeting MmpL3.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.