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Article

Characterization of DprE1-Mediated Benzothiazinone Resistance in Mycobacterium tuberculosis.

Antimicrobial agents and chemotherapy - 1 Nov 2016

Foo Caroline Shi-Yan, Lechartier Benoit, Kolly Gaëlle S, Boy-Röttger Stefanie, Neres João, Rybniker Jan, Lupien Andréanne, Sala Claudia, Piton Jérémie, Cole Stewart T

Abstract excerpt

Benzothiazinones (BTZs) are a class of compounds found to be extremely potent against both drug-susceptible and drug-resistant Mycobacterium tuberculosis strains. The potency of BTZs is explained by their specificity for their target decaprenylphosphoryl-d-ribose oxidase (DprE1), in particular by covalent binding of the activated form of the compound to the critical cysteine 387 residue of the enzyme. To probe...

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Identifiers

PMID: 27527085
DOI: 10.1128/AAC.01523-16
PMCID: PMC5075049

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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