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Leukemia-derived apelin selects endothelial niche clones to promote tumorigenesis

2024-09-13

Abstract excerpt

Hematopoietic stem cells are regulated by endothelial and mesenchymal stromal cells in the marrow niche1-3. Leukemogenesis was long believed to be solely driven by genetic perturbations in hematopoietic cells but introduction of genetic mutations in the microenvironment demonstrated the ability of niche cells to drive disease progression4-8. The mechanisms by which the stem cell niche induces leukemia remain poorl...

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Literature Corpus work
6ef16d0d-052d-5a36-b170-9156e1066e58
DOI
10.1101/2024.09.09.612077
Open publication

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Leukemia-derived apelin selects endothelial niche clones to promote tumorigenesisDOI 10.1101/2024.09.09.612077
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