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Article

Decitabine and its role in the treatment of hematopoietic malignancies

1 Jan 2007

Abstract excerpt

DNA methylation is responsible for abnormal silencing of many genes, including tumor suppressor genes, in cancer. Decitabine, an S-phase specific inhibitor of DNA methyltransferase, has been shown to decrease levels of abnormal methylation in neoplasia. Though initially investigated at high doses as a cytotoxic agent, recent studies show that when administered at low doses, the hypomethylating activity of...

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PMID: 17701577
DOI: 10.1080/10428190701471981

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