Article

Calcium Binding Affinity in the Mutational Landscape of Troponin-C: Free Energy Calculation, Coevolution Modeling and Machine Learning

2024-09-09

Abstract excerpt

Mutation in calcium-binding proteins (CBPs) can significantly influence Ca 2+ binding affinity (BA), resulting in substantial impairment in the signaling process and leading to several lethal diseases. The knowledge behind the changes in the binding affinity can help in understanding the signaling process and designing inhibitors for therapeutic usage. However, accurate prediction of BA for a large number of muta...

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Literature Corpus work: 6ed7c70d-f7c7-59a9-9b6c-d10a4bb2ee58
DOI: 10.1101/2024.09.09.612070

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