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Article

Protein phenotype diagnosis of autosomal dominant calmodulin mutations causing irregular heart rhythms.

Journal of cellular biochemistry - 1 Nov 2018

Shaik Noor A, Awan Zuhier A, Verma Prashant K, Elango Ramu, Banaganapalli Babajan

Abstract excerpt

The life-threatening group of irregular cardiac rhythmic disorders also known as Cardiac Arrhythmias (CA) are caused by mutations in highly conserved Calmodulin (CALM/CaM) genes. Herein, we present a multidimensional approach to diagnose changes in phenotypic, stability, and Ca2+ ion binding properties of CA-causing mutations. Mutation pathogenicity was determined by diverse computational machine learning...

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Identifiers

PMID: 29932249
DOI: 10.1002/jcb.26834

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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