Article

Genome organization regulates nuclear pore complex formation and promotes differentiation during Drosophila oogenesis

2023-11-16

Abstract excerpt

Genome organization can regulate gene expression and promote cell fate transitions. The differentiation of germline stem cells (GSCs) to oocytes in Drosophila involves changes in genome organization mediated by heterochromatin and the nuclear pore complex (NPC). Heterochromatin represses germ-cell genes during differentiation and NPCs anchor these silenced genes to the nuclear periphery, maintaining silencing to a...

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Literature Corpus work: 6ec9b19e-15d7-56d7-ab37-8b5bcb86d737
DOI: 10.1101/2023.11.15.567233

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