Back to search

Article

NMNAT promotes glioma growth through regulating post-translational modifications of p53 to inhibit apoptosis

2021-05-13

Abstract excerpt

<h4>ABSTRACT</h4> Gliomas are highly malignant brain tumors with poor prognosis and short survival. NAD + has been shown to impact multiple processes that are dysregulated in cancer; however, anti-cancer therapies targeting NAD + synthesis have been unsuccessful due to insufficient mechanistic understanding. Here we adapted a Drosophila glial neoplasia model and discovered the genetic requirement for NAD + sy...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
6ec1a55c-7528-52b5-9e3a-e59980d84fd4
DOI
10.1101/2021.05.12.443736
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
NMNAT promotes glioma growth through regulating post-translational modifications of p53 to inhibit apoptosisDOI 10.1101/2021.05.12.443736
NMNAT promotes glioma growth through regulating post-translational modifications of P53 to inhibit apoptosisSemantic proximity
NAMPT as a Dedifferentiation-Inducer Gene: NAD+ as Core Axis for Glioma Cancer Stem-Like Cells MaintenanceSemantic proximity
Targeting inhibition of prognosis-related nicotinamide metabolism genes, including poly (ADP-ribose) polymerase 9 (PARP-9) attenuates glioma progressionSemantic proximity
Mutant Nmnat1 leads to a retina-specific decrease of NAD+ accompanied by increased poly(ADP-ribose) in a mouse model of NMNAT1-associated retinal degeneration.Semantic proximity
Nuclear NAD <sup>+</sup> -biosynthetic enzyme NMNAT1 facilitates survival of developing retinal neuronsSemantic proximity
A prognostic NAD+ metabolism-related gene signature for predicting response to immune checkpoint inhibitor in gliomaSemantic proximity
Overexpression of NNMT in Glioma Aggravates Tumor Cell Progression: An Emerging Therapeutic TargetSemantic proximity
An NAD+-dependent transcriptional program governs self-renewal and radiation resistance in glioblastoma.Semantic proximity
NAD+ biosynthesis as a collateral lethality target for precision oncologySemantic proximity
Extensive regulation of nicotinate phosphoribosyltransferase (NAPRT) expression in human tissues and tumors.Semantic proximity
Nicotinamide N-Methyltransferase in Acquisition of Stem Cell Properties and Therapy Resistance in CancerSemantic proximity
Advances in NAD-Lowering Agents for Cancer TreatmentSemantic proximity
Select a neighboring publication to make it the new centre.