Article

NAD+ biosynthesis as a collateral lethality target for precision oncology

2022-12-15

Abstract excerpt

<h4>ABSTRACT</h4> Genomic deletion of tumor suppressor genes (TSG) often encompasses neighboring genes which may be members of multi-gene families encoding cell essential functions. These genomic events create targetable cancer-specific vulnerabilities, termed “collateral lethality” as illustrated by homozygous deletion of the glycolytic gene ENO1 , which sensitizes glioblastoma (GBM) cells to inhibition of its...

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Literature Corpus work: 470bc1a2-8067-55b5-8d91-41c6b389f170
DOI: 10.1101/2022.12.13.518967

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