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Advances in NAD-Lowering Agents for Cancer Treatment

14 May 2021

Abstract excerpt

Nicotinamide adenine dinucleotide (NAD) is an essential redox cofactor, but it also acts as a substrate for NAD-consuming enzymes, regulating cellular events such as DNA repair and gene expression. Since such processes are fundamental to support cancer cell survival and proliferation, sustained NAD production is a hallmark of many types of neoplasms. Depleting intratumor NAD levels, mainly through interference...

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PMID: 34068917
DOI: 10.3390/nu13051665

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