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Article

NMNAT promotes glioma growth through regulating post-translational modifications of P53 to inhibit apoptosis

11 Nov 2021

Abstract excerpt

Gliomas are highly malignant brain tumors with poor prognosis and short survival. NAD + has been shown to impact multiple processes that are dysregulated in cancer; however, anti-cancer therapies targeting NAD + synthesis have had limited success due to insufficient mechanistic understanding. Here, we adapted a Drosophila glial neoplasia model and discovered the genetic requirement for NAD + synthase nicotinamide...

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PMID: 34919052
DOI: 10.7554/elife.70046

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