Article

Leveraging allele-specific expression to refine fine-mapping for eQTL studies

2018-01-31

Abstract excerpt

Many disease risk loci identified in genome-wide association studies are present in non-coding regions of the genome. It is hypothesized that these variants affect complex traits by acting as expression quantitative trait loci (eQTLs) that influence expression of nearby genes. This indicates that many causal variants for complex traits are likely to be causal variants for gene expression. Hence, identifying causal...

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Literature Corpus work: 3d57a518-7dfc-5c0e-b4c3-98de5136a7d2
DOI: 10.1101/257279

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