Elevated levels of the cytokine LIGHT in Crohn’s disease

Abstract excerpt

LIGHT, encoded by the TNFSF14 gene, is a cytokine belonging to the tumor necrosis factor superfamily. Upon binding to its receptors, HVEM and LTBR, it activates inflammatory responses. We used a single-molecule immunoassay to determine the circulating levels of free LIGHT in plasma from pediatric patients with Crohn’s disease (N = 183) and a panel of healthy pediatric reference samples (N = 9). LIGHT levels were g...

Topics

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• Biological Availability
• Coculture Techniques
• HeLa Cells
• Inflammation Mediators
• Models, Immunological
• Mutagenesis, Site-Directed
• NF-kappa B
• Protein Binding

Identifiers and source

Literature Corpus work

6e9b7d43-7b14-53d9-963c-6204e203934f

DOI

10.1101/2021.07.16.21260656