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Article

HVEM structures and mutants reveal distinct functions of binding to LIGHT and BTLA/CD160.

The Journal of experimental medicine - 6 Dec 2021

Liu Weifeng, Chou Ting-Fang, Garrett-Thomson Sarah C, Seo Goo-Young, Fedorov Elena, Ramagopal Udupi A, Bonanno Jeffrey B, Wang Qingyang, Kim Kenneth, Garforth Scott J, Kakugawa Kiyokazu, Cheroutre Hilde, Kronenberg Mitchell, Almo Steven C

Abstract excerpt

HVEM is a TNF (tumor necrosis factor) receptor contributing to a broad range of immune functions involving diverse cell types. It interacts with a TNF ligand, LIGHT, and immunoglobulin (Ig) superfamily members BTLA and CD160. Assessing the functional impact of HVEM binding to specific ligands in different settings has been complicated by the multiple interactions of HVEM and HVEM binding partners. To dissect the...

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PMID: 34709351
DOI: 10.1084/jem.20211112
PMCID: PMC8558838

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HVEM structures and mutants reveal distinct functions of binding to LIGHT and BTLA/CD160.PMID 34709351Read ↗

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